What is Polycystic Kidney Disease (PKD)?

Polycystic kidney disease (PKD) is a genetic disorder characterized by the growth of numerous fluid-filled cysts in the kidneys. These cysts gradually replace normal kidney tissue, impairing kidney function and leading to complications such as high blood pressure, kidney stones, urinary tract infections, and kidney failure. PKD is one of the most common inherited kidney disorders, affecting both adults and children. There are two main types of PKD: autosomal dominant PKD (ADPKD), which is the most common form and typically manifests in adulthood, and autosomal recessive PKD (ARPKD), which is less common and usually presents in infancy or childhood.

Common Symptoms of a Polycystic Kidney Disease​

Abdominal or Flank Pain

Dull, aching pain in the abdomen or sides (flanks) due to the enlargement of kidney cysts or complications such as bleeding within the cysts.

Hypertension

High blood pressure, which can result from the compression of blood vessels by kidney cysts and may worsen kidney function over time.

Hematuria

Presence of blood in the urine, often due to the rupture or bleeding of kidney cysts, urinary tract infections, or kidney stones.

Urinary Tract Infections (UTIs)

Recurrent urinary tract infections, which may occur due to urinary stasis caused by obstruction from kidney cysts or impaired kidney function.

Kidney Stones

Formation of kidney stones, resulting from mineral deposits in the urine and obstruction of the urinary tract by kidney cysts.

Increased Urinary Frequency

Increased frequency of urination, especially at night (nocturia), due to decreased kidney function or bladder irritation.

Whom to Consult?​ and When to Seek Medical Advice?​

If you have a family history of polycystic kidney disease or experience symptoms suggestive of PKD, it’s essential to seek medical evaluation and appropriate management at SRM Global Hospitals, Chennai.
Dr. S. Krishna Kumar

Dr. S. Krishna Kumar

MBBS, MD, DM

Senior Consultant

Dr. Tanuj Moses Lamech

Dr. Tanuj Moses Lamech

MBBS, MD, DM, DNB

Visiting Consultant

Dr. Mathew Gerry George

Dr. Mathew Gerry George

MBBS, MD, DNB

Visiting Consultant

Dr. Jayaprakash. V

Dr. Jayaprakash. V

MBBS, MD, DM, DNB

Visiting Consultant

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Common FAQs About Polycystic Kidney Disease

Q: What causes polycystic kidney disease?

A: Polycystic kidney disease is a genetic disorder caused by mutations in specific genes (such as PKD1 or PKD2) that regulate the development and function of kidney cells. These mutations lead to the abnormal growth and proliferation of kidney cysts over time.

Q: How is polycystic kidney disease diagnosed?

A: Diagnosis of polycystic kidney disease typically involves a combination of medical history, physical examination, imaging studies (such as ultrasound, CT scan, or MRI), and genetic testing to assess the size, number, and distribution of kidney cysts and confirm the genetic basis of the condition.

Q: What is the treatment for polycystic kidney disease?

A: Treatment for polycystic kidney disease aims to manage symptoms, slow disease progression, and prevent complications. It may include lifestyle modifications (such as dietary changes, blood pressure control), medications (such as pain relievers, blood pressure medications), surveillance for complications (such as kidney stones or infections), and, in some cases, renal replacement therapy (such as dialysis or kidney transplantation) for end-stage kidney disease.

Q: Can polycystic kidney disease be prevented?

A: As polycystic kidney disease is a genetic disorder, it cannot be prevented entirely. However, genetic counseling and screening may be recommended for individuals with a family history of PKD to assess the risk of inheritance and provide guidance on family planning options.